MK-801 (Dizocilpine)
MK-801 (Dizocilpine)
CAS: 77086-21-6
Molecular Formula: C16H15N
MK-801 (Dizocilpine) - Names and Identifiers
MK-801 (Dizocilpine) - Physico-chemical Properties
| Molecular Formula | C16H15N |
| Molar Mass | 221.3 |
| Density | 1.144±0.06 g/cm3(Predicted) |
| Melting Point | 68.5-69° |
| Boling Point | 320.3±11.0 °C(Predicted) |
| Specific Rotation(α) | 20589 +161.4° (c = 0.038 g/2 ml ethanol) |
| pKa | 7.96±0.40(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | Dizocilpine (MK-801) progressively suppresses of current induced by NMDA. Mg 2+ (10 mM) prevents Dizocilpine from blocking the N-Me-D-Asp-induced current, even when Dizocilpine is applied for a long time in the presence of NMDA. Dizocilpine blocks NMDA-activated single-channel activity in outside-out patches. Dizocilpine (MK-801; <500 μM) inhibits activation of microglia induced by LPS with increased Cox-2 protein expression in BV-2 cells. Dizocilpine (<500 μM) reduces microglial TNF-α output with an EC 50 of 400 μM in BV-2 cells. |
| In vivo study | Dizocilpine (MK 801) (1 mg/kg) treatment before each METH injection reduces the extent of DA depletion by 55% in striatal of mice. Dizocilpine (MK 801) (1 mg/kg) also attenuates the effects of METH on microglial activation in striatal of mice. Dizocilpine ((+)-MK 801) (0.05, 0.2 mg/kg, i.p.) attenuates subsequent cocaine-primed reinstatement without disruption in rats. Dizocilpine (MK 801) (0.2 mg/kg, i.p.) prior to two reactivation sessions in the home cage shows no suppression on subsequent cocaine-primed reinstatement. Dizocilpine (0.03, 0.1, 0.3 and 1 mg/kg, i.p.) significantly increases the ambulation of mice at 0.3 and 1 mg/kg, but not at 0.03 and 0.1 mg/kg. |
MK-801 (Dizocilpine) - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 4.519 ml | 22.594 ml | 45.188 ml |
| 5 mM | 0.904 ml | 4.519 ml | 9.038 ml |
| 10 mM | 0.452 ml | 2.259 ml | 4.519 ml |
| 5 mM | 0.09 ml | 0.452 ml | 0.904 ml |
Last Update：2024-01-02 23:10:35
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Product Name: MK-801 (Dizocilpine) Visit Supplier Webpage Request for quotationCAS: 77086-21-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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